EURESTOP WG Meeting – Brussels, Belgium
13 June 2023
INFO:
09:00 – 09:10 Welcome – Mattia Mori, Italy (Chair of the Action)
09:10 – 10:00 Stephen Hawser (CEO of IHMA Europe Sàrl, Switzerland): Strategies for Monitoring and Combating Antimicrobial Resistance
10:00 – 10:10 Younes Smani, Spain, WG2 leader
10:10 – 10:20 Carole Devaux, Luxembourg, WG3 leader
10:20 – 10:30 Tomislav Mestrovic, Croatia, Stakeholders coordinator
10:30 – 10:40 Cristina Nativi, Italy, Science Communication Coordinator
10:40 – 11:10 Coffee break
11:10 – 11:20 Priyanka Sahariah, Iceland, Grant Awarding Coordinator
11:20 – 11:35 Didem Şen Karaman, Turkey, YR&Is Coordinator
11:35 – 11:50 Giordano Rampioni, University Roma Tre, Italy: Novel therapeutic approaches against Pseudomonas aeruginosa.
11:50 – 12:05 Martijn Riool, Amsterdam institute for Infection and Immunity, The Netherlands: Novel Synthetic Antimicrobial and Anti-biofilm Peptides (SAAPs)- containing coatings to prevent biomaterial-associated infection.
12:05 – 12:20 Alexander Titz, Saarland University, Germany: Fighting ESKAPE bacteria: Lectin inhibitors as antibiofilm agents and probes for imaging/drug targeting
12:20 – 13:45 Lunch
13:45 – 14:00 Ghadeer Suaifan, The University of Jordan, Jordan: Development of colorimetric biosensors for pathogenic bacterial detection
14:00 – 14:15 Maciej Kachanowski, National Veterinary Research Institute, Poland: Phenotypic and genotypic profiling of antimicrobial resistance in Streptococcus suis strains isolated from Polish swine populations.
14:15 – 14:25 Dana Reichmann, Israel, WG1 leader
14:25 – 15:05 Round Table #1 – Creation of a virtual/physical EURESTOP chemoteque (moderator: Mark Broenstrup)
15:05 – 15:30 Coffee break
15:30 – 16:10 Round Table #2 – Enhancing WG2/WG3 interactions (moderators: Younes Smani & Carole Devaux)
16:10 – 16:50 Round Table #3 – Creation of a virtual collection of strains (moderator: Rossella Grande)
16:50 – 17:00 Closing remarks and next steps/events
First meeting – Lisbon, Portugal
26-27 January 2023
European Network for diagnosis and treatment of antibiotic-resistant bacterial infections
Universidade Lusófona de Humanidades e Tecnologias – Lisbon, Portugal
INFO:
26th January 2023
https://videoconf-colibri.zoom.us/j/91185124432
8:15 – 9:00 Registration of participants
9:00 – 9:15 Opening:
Mattia Mori – CA21145 Chair
L. Monteiro Rodrigues – CBIOS Director
Patrícia Rijo – Local organizer
Session 1 | Chairman: CRISTINA NATIVI (Italy)
9:15 -10:00 Invited Expert: Marco Maria D’Andrea Università di Roma “Tor Vergata”, Italy
Antibiotics and antibiotic resistance: lessons from the past to guide future actions
10:00 -10:15 Magne Sydnes University of Stavanger, Norway
Post-use photodecomposition – quicker removal of antimicrobial agents from the environment
10:15 -10:30 Abidelfatah Nasser Beitberl College of Education, Israel
Environmental Dissemination of antibiotic resistant bacteria (ARB) and genes (ARG) by the discharge of Wastewater Effluents
10:30 – 10:45 Vladimír Křen Czech Academy of Sciences, Czech Republic
Flavonolignans from silymarin as MDR inhibitors
10:45 – 11:15 Coffee break
Session 2 | Chairman: DANA REICHMANN (Israel)
11:15 – 11:30 Simone Carradori University of Chieti-Pescara, Italy
Pseudomonas aeruginosa carbonic anhydrase inhibitors as innovative antibacterial agents to combat antibiotic resistance: ciprofloxacin derivatives
11:30 – 11:45 A. Basak Kayitmazer Bogazici University, Turkey
Soft Matter for Understanding and Treating Antibiotic-Resistant Bacterial Infections
11:45 – 12:00 Ivanka Tsakovska Bulgarian Academy of Sciences, Bulgaria
Development and application of in silico approaches to predict pharmacologial/toxic effects of bioactive compounds
12:00 – 12:15 Nuno R. Candeias University of Aveiro, Portugal
Phenolic Mannich bases as antibacterials agents for Staphylococcus aureus
12:15 – 12:30 Yves Mèly University of Strasbourg, France
Developing new strategies to image, target and kill gram negative bacteria
12:30 – 12:45 Lul Raka National Institute of Public Health of Kosova, Kosovo
Addressing antimicrobial resistance in Kosova
12:45 – 14:30 Lunch break (& group picture at 14:20 in front of the Auditorium entrance)
Session 3 | Chairman: CAROLE DEVAUX (Luxembourg)
14:30 – 14:45 Vera M. S. Isca Universidade Lusófona, Portugal
Antimicrobial screening of Plectranthus extracts for applications against antibiotic resistant bacterial infections
14:45 – 15:00 Ana Martins Biological Research Centre, Hungary
Laboratory evolution as a key tool in antimicrobial development
15:00 – 15:15 Ismail Ocsoy Erciyes University, Turkey
Development of natural and synthetic anthocyanin incorporated phenotypic tests for colorimetric, fast and sensitive detection of antibiotic resistance bacteria in clinic
15:15 – 15:30 Constantinos Athanassopoulos University of Patras, Greece
Natural product antibacterial agents and rediscovery of old antibiotics
15:30 – 15:45 Michail Christodoulou University of Milan, Italy
4-(1,2,2-triphenylvinyl)aniline as self-assembling inducer
15:45 – 16:15 Coffee break
16:15 – 16:30 Matthew Borg COST Association
Q&A – reimbursement rules and eligible expenses
16:15 – 17.15 Working Groups Meeting
WG1 – Room D.1.11
Remote connection: https://videoconf-colibri.zoom.us/j/99354119338 Meeting ID: 99354119338
WG2 – Room D.1.13
Remote connection: https://videoconf-colibri.zoom.us/j/96883839475 Meeting ID: 968 8383 9475
WG3 –conference auditorium
Remote connection: https://videoconf-colibri.zoom.us/j/91185124432 (same as the main conference)
17:15 – 18:45 MC Meeting – ONLY FOR MC MEMBERS
Conference auditorium
Social dinner – Chimarrão Campo Grande – 19:30-22:00 (https://chimarrao.pt/)
27th January 2023
https://videoconf-colibri.zoom.us/j/91185124432
Session 4 | Chairman: PATRICIA RIJO (Portugal)
9:15 – 10:00 Invited Expert: Artur Silva University of Aveiro, Portugal
Biologically active oxygen and nitrogen heterocyclic compounds from cycloaddition and conjugate addition reactions on chromones
10:00 – 10:15 Tomislav Mestrovic University North, University centre Varaždin, Croatia
Estimating the burden of bacterial antimicrobial resistance in Europe and beyond: a systematic data- driven approach for research and implementation priority setting
10:15 – 10:30 Stephen J. Fey CelVivo ApS, Denmark
Culture Conditions Matter
10:30 – 10:45 Fabienne Dumoulin Acıbadem Mehmet Ali Aydınlar University, Turkey
Photodynamic therapy – Are light-triggered oxidative damages the magic solution to AMR?
10:45 – 11:15 Coffee break
Session 5 | Chairman: PRIYANKA SAHARIAH (Iceland)
11:15 – 11:30 Younes Smani University of Pablo de Olavide, Spain
Innovative antimicrobial strategy for the treatment of MDR bacterial infection
11:30 – 11:45 Bengt Erik Haug University of Bergen, Norway
Novel ligands for the flavin mononucleotide riboswitch
11:45 – 12:00 Bruno L. Victor University of Lisbon, Portugal
How can the Structure-based Molecular Modeling group from FCUL boost the EURESTOP
12:00 – 12:15 Kaja Kasemets National Institute of Chemical Physics and Biophysics, Estonia
Antimicrobial chitosan-nanocomposites for biomedical applications
12:15 – 12:30 Maria M. M. Santos University of Lisbon, Portugal
Spirooxindoles for targeting cancer and malaria. Perspectives of antibacterial activity
12:30 – 12:45 Giorgia Giovannini Swiss Federal Laboratories for Materials Science & Technology, Switzerland
Diagnosis and treatment of bacterial infections
12:45 – 14:30 Lunch break
Session 6 | Chairman: YOUNES SMANI (Spain)
14:30 – 14:45 Rossella Grande University of Chieti-Pescara, Italy
Antimicrobial and Antibiofilm Activities of Carvacrol and Thymol: Effective Carbonic Anhydrase Inhibitors versus Helicobacter pylori
14:45 – 15:00 Gabrielle Bangay Universidade Lusófona, Portugal
Chemical design of halimane diterpene for enhanced antimicrobial activity
15:00 – 15:15 Ryszard Ostaszewski Institute of Organic Chemistry, Poland
Application of multicomponent reactions for the synthesis of a new potential antimicrobial drugs
15:15 – 15:30 Ivana Kovačević University of Novi Sad, Serbia
Natural products with γ-butyrolactone moiety as potential antibiotics
15:30 – 15:45 Sanja Glisic Institute of Nuclear Sciences VINCA, Serbia
Efficient in silico approach for selection therapeutics against DR bacteria and identification of new therapeutic targets
15:45 – 16:00 Entela Haloci University of Medicine, Albania
A comparative study of antibacterial and antifungal activities of some essential oils
16:00 – 16:30 Coffee break
Session 7 | Chairman: TOMISLAV MESTROVIC (Croatia)
16:30 – 16:45 Nace Zidar University of Ljubljana, Slovenia
Discovery of new inhibitors of DNA gyrase and topoisomerase IV to overcome antimicrobial resistance
16:45 – 17:00 Paulo J. Costa University of Lisbon, Portugal
Studying molecular recognition phenomena using computational tools: the case of halogenated drugs
17:00 – 17:15 Jitka Viktorova University of Chemistry and Technology Prague, Czech Republic
Antibiotic resistance platform for high-throughput screening of adjuvants for combination therapies
17:15 – 17:30 Carole Devaux Luxembourg Institute of Health, Luxembourg
Development of immunotherapeutic complexes eliciting complement activation towards multidrug- resistant Pseudomonas aeruginosa
17:30 – 17:40 – CA21145 Organizing Committee
Closing remarks, next meetings and activities
First Training School – Lisbon, Portugal
23-25 January 2023
Training school in Bioinformatics and Computational tools in antibacterial research
Universidade Lusófona de Humanidades e Tecnologias – Lisbon, Portugal
INFO:
23 January, 2023:
Ligand- and Structure-based approaches in drug design
Trainers: Daniel Santos (Portugal) and Petko Alov (Bulgaria)
08:30 – 09:00 Registration of participants
09:00 – 09:15 Opening:
L. Monteiro Rodrigues (CBIOS Director),
Patrícia Rijo– Local organizer
Mattia Mori (Action Chair)
09:15 – 13:00 Session #1 Daniel Santos and Petko Alov
13:00 – 14:00 Lunch break
14:00 – 17:30 Session #2 Daniel Santos and Petko Alov
Daniel Santos: Hands-on approach for discovering efflux modulators using a structure- based approach
Petko Alov: Ligand-based in silico approaches for evaluation of ADME/Tox properties of biologically active compounds
24 January, 2023:
Molecular dynamics and metadynamics simulations
Trainers: Alejandro Seco (Spain) and Daniel Conde Torres (Spain)
09:00 – 13:00 Session #1 Alejandro Seco and Daniel Conde Torres
13:00 – 14:00 Lunch break
14:00 – 17:30 Session #2 Alejandro Seco and Daniel Conde Torres
Alejandro Seco: Molecular Dynamics simulations to explore innate immune systems peptides and their cell membrane interactions: SuPepMem database
Daniel Conde Torres: Insights into the mechanisms of antimicrobial peptide action through metadynamics simulations
Introduction to the use of molecular dynamics simulations in the study of antibiotic- resistant bacterial infections
- Hands-on case study: Coarse-grained MD simulation of an antimicrobial peptide interacting with a bacteria model membrane. Setting up the simulations and utilizing supercomputer resources.
- Analysis and interpretation of the results from MD simulations
- Utilizing augmented and virtual reality visualization tools for enhanced analysis and understanding of the simulation results
25 January, 2023
Proteomics data analysis in microbiology
Trainer: Dana Reichmann (Israel)
09:00 – 13:00 Session #1 Dana Reichmann
13:00 – 14:00 Lunch break
14:00 – 17:30 Session #2 Dana Reichmann
Dana Reichmann: Applications of quantitative and structural proteomics in microbiology
Dana Reichmann: Introduction into proteomics data analysis